在患有子宫内膜异位症的妇女手术前和手术后血液炎症参数的比较:回顾性队列研究

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Onur Yavuz¹, Asli Akdoner², Kadir Alper Mankan²

¹Department of Obstetrics and Gynecology, Dokuz Eylul University School of Medicine, Balcova/Izmir, 35330, Turkey. onur.yavuz@deu.edu.tr.

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概括

这项研究发现,血液炎症标志物如中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 在子宫内膜异位症的手术后增加. 然而,癌症抗原125 (CA-125) 水平下降,保持其预测值.

科学领域:

妇科妇科妇科妇科
炎症标志物炎症标志物
外科手术的结果

背景情况:

子宫内膜异位症显著影响女性的健康.
了解炎症标志物在子宫内膜异位症中的作用对于诊断和管理至关重要.
有限的研究比较了治疗前和治疗后的血液学参数.

研究的目的:

为了比较患有子宫内膜异位症的女性手术前和手术后的血液学炎症参数.
评估标记物的变化,例如中性细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR),血小板与淋巴细胞的比率 (PLR) 和癌症抗原125 (CA-125).
确定这些标志物对子宫内膜异位症的预测值.

主要方法:

分析了411名接受腹腔镜检查的患者 (2018-2023) 的数据.
分类为卵巢内膜瘤,其他良性卵巢囊,1-2期子宫内膜症和3-4期子宫内膜症.
使用统计测试 (Kruskal Wallis,Mann-Whitney U,Wilcoxon signed-rank,Chi-square,Fisher precision) 进行血液学标记和超声波前后发现的比较.
接收器操作特征 (ROC) 分析以确定预测的截止值.

主要成果:

与手术前水平相比,观察到NLR,MLR和PLR的术后增加.
在整体组和3-4期子宫内膜异位症和良性卵巢囊子组中,CA-125水平在术后降低.
已确立的RDW (>13.5),PLR (>123.4) 和CA-125 (>35) 的截止值作为子宫内膜异位症的预测指标.

结论:

在随访期间,CA-125仍然是子宫内膜异位症的有效标志物.
像NLR和PLR这样的血液炎症标志物在手术治疗后显示出显著的变化.
这项研究提供了关于子宫内膜异位症管理中的炎症标志物的动态变化的宝贵见解.

关键词:

在 CA-125 文件中,您可以使用 CA-125 文件.子宫内膜异位症是什么?子宫内膜异位症是什么中性粒细胞与淋巴细胞的比率.血小板与淋巴细胞的比例.

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