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Updated: Sep 16, 2025

Modeling an Enzyme Active Site using Molecular Visualization Freeware
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Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

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冠状病毒主要蛋白酶的酶动力学模型,包括二元化和连接体结合

Van N T La1, Lulu Kang2, David D L Minh3

  • 1Department of Biology, Illinois Institute of Technology, Chicago, Illinois.

Biophysical journal
|July 6, 2025
PubMed
概括

这项研究模拟了冠状病毒主要蛋白酶 (MPro) 活性,揭示了像GC376这样的抑制剂如何诱导二分化和合作性,与基质不同,以解释两相反应.

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Induced-fit Model

Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
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Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
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