慢性低剂量X射线暴露对放射学工作人员甲状腺功能和血细胞参数的分子和细胞影响
Salah Qadir Mahmood1, Bakhtyar Kamal Talabany2, Taib Ahmed Hama-Soor3
1Anesthesia Department, Sulaimani Technical Institute, Sulaimani Polytechnic University, Sulaimaniyah, Iraq. salah.mahmood@spu.edu.iq.
概括
放射科工作人员长期低剂量X射线暴露可能会影响甲状腺功能和血细胞计数. 特定的甲状腺刺激激素 (TSH) 和三甲状腺素 (T3) 水平,以及红细胞分布宽度 (RDW-CV),与职业因素有显著的相关性.
科学领域:
- 职业健康 职业健康 职业健康
- 放射学 放射学是一门学科.
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
背景情况:
- 职业暴露于电离辐射,如X射线,是医疗保健专业人员的担忧.
- 了解低剂量辐射对健康的长期影响对于实施有效的安全措施至关重要.
研究的目的:
- 调查慢性低剂量职业X射线暴露对放射学工作人员甲状腺功能和血液学参数的影响.
- 确定辐射暴露水平,工作时间和特定健康指标之间的潜在相关性.
主要方法:
- 一项涉及136名放射学和辐射相关员工的横截面研究.
- 使用超声波和血清测量三甲状腺素 (T3),甲状腺素 (T4) 和甲状腺刺激激素 (TSH) 的甲状腺状况评估.
- 分析了全血细胞计数 (CBC),以评估血液学参数.
主要成果:
- 在甲状腺激素或结构上没有观察到任何显著的性别差异.
- 甲状腺刺激激素 (TSH) 水平与职业群体有显著的相关性 (P=0.016),T3水平与工作时间有显著的相关性 (P=0.03).
- 放射科医生显示红细胞分布宽度变化系数 (RDW-CV) 比放射科医生和其他工作人员 (P=0.009) 高. 在淋巴细胞计数,血红蛋白,红细胞和血红度方面发现了显著的性别差异. 在男性中,白细胞 (WBC) 和平均体质血红蛋白度 (MCHC) 随着工作时间的增加而波动.
结论:
- 慢性,低剂量的X射线暴露可能会影响放射学专业人员的甲状腺激素调节和血液形成.
- 结果表明对TSH,T3和特定CBC参数的潜在影响,需要进一步调查.
- 需要进一步的研究来了解潜在的机制,并完善职业健康的辐射安全协议.
相关概念视频
Biological Effects of Radiation
15.9K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.9K
X-ray Imaging
6.8K
German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
6.8K
Radiological Investigation I: X-ray and CT
411
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
411
Functions of Thyroid Hormones
3.1K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.1K
Imaging Studies for Cardiovascular System III: X-Ray
297
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
297
Synthesis and Regulation of Thyroid Hormones
5.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.1K


