温丹开通过调节肠道微生物群和托代谢来对失眠产生治疗作用
Yuan Tian1, Jianguo Meng2, Dezhu Zhang3
1Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi University of Chinese Medicine, Xianyang 712046, PR China.
概括
温丹 (Wendan Decoction,简称WDD) 通过调节肠道微生物群和酸盐代谢来改善失眠,增强肠-大脑轴. 这种传统疗法可以缓解焦虑和神经元损伤,为睡眠障碍提供了一种新的治疗方法.
科学领域:
- 综合医学是一个整体的医学.
- 微生物组研究的研究.
- 神经科学是一个神经科学.
背景情况:
- 失眠是一个重大的公共卫生挑战.
- 温丹 (Wendan Decoction,简称WDD) 在治疗失眠方面显得有前途,但其机制尚不清楚.
研究的目的:
- 阐明WDD在治疗失眠中的机制.
- 研究肠道微生物群和新陈代谢在WDD疗效中的作用.
主要方法:
- 使用UHPLC-Orbitrap Exploris/MS.分析了WDD的组成.
- 通过行为,生化和组织学分析,通过PCPA诱导的失眠大鼠评估WDD的疗效.
- 集成的16S rRNA测序,代谢学和网络药理学,以探索机制.
- 使用抗生素治疗和便微生物群移植 (FMT) 验证了肠道微生物群的作用.
主要成果:
- 在老鼠中,WDD改善了睡眠质量,减少了焦虑,并减轻了神经元损伤.
- WDD调节了神经递质水平,减少了肠道,血清和大脑的炎症.
- WDD使肠道微生物群正常化,并调节了托代谢,特别是金氨酸通路.
- FMT证实了肠道微生物群在WDD治疗效果中的关键作用.
结论:
- 通过调节微生物群-肠-大脑轴,WDD可以改善失眠.
- WDD调节肠道微生物群和酸盐代谢,以恢复神经递质平衡并减少炎症.
- 这项研究支持WDD作为治疗失眠的治疗剂的潜力.
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