多药对中风严重程度和急性缺血性中风的功能结果的影响
Hiroki Takatsu1, Hidetaka Mitsumura1, Junichiro Takahashi1
1Department of Neurology, the Jikei University School of Medicine, Tokyo, Japan.
概括
脑中风前多药与急性缺血性脑中风患者中风严重程度的增加有关. 然而,这种药物使用模式并没有影响他们在90天后的功能恢复结果.
科学领域:
- 神经学 神经学
- 临床医学 临床医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多药学,即使用多种药物,在医疗保健中构成了越来越大的挑战.
- 它与患者的不良健康结果有关.
- 了解它对中风的影响对于患者护理至关重要.
研究的目的:
- 调查中风前多药和中风严重程度之间的关联.
- 检查中风前多药和急性缺血性中风 (AIS) 后的功能结果之间的关系.
主要方法:
- 对1,060名AIS患者的回顾性审查,这些患者在发病后7天内住院.
- 患者分为多药 (≥5种药物/天) 和非多药组.
- 通过NIHSS评估中风严重程度;90天后通过mRS评估功能结果;进行多变量回归分析.
主要成果:
- 38%的患者使用多药.
- 多药性与中度至重度中风 (NIHSS 6-42) (OR 1.57,P=0.04) 独立相关.
- 多药性与90天后的功能不良结果 (mRS 3-6) 没有关联.
结论:
- 脑卒中前的多药性治疗是与AIS患者中风严重程度增加相关的重要因素.
- 尽管与严重性有关,但多药似乎没有影响中风后的功能恢复.
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