单剂量 (10毫克) псилоцибин可降低成年痴迷强迫症患者的症状:一个药理学挑战研究
Luca Pellegrini1, Naomi A Fineberg2, Sorcha O'Connor3
1School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom; Centre for Neuropsychopharmacology and Psychedelic Research, Hammersmith Hospital Campus, Imperial College, London, United Kingdom; Department of Medicine, Surgery and Health Sciences, University of Trieste, Italy; Azienda Sanitaria Universitaria Giuliano-Isontina - ASUGI, UCO Clinica Psichiatrica, Trieste, Italy.
Comprehensive psychiatry
|July 6, 2025
概括
10毫克的 псилоцибин剂量显示出对强迫症 (OCD) 的潜在疗效,可显著减少强迫症症状长达一周. 这种迷幻化合物在那些对传统的SSRI治疗无反应的患者中被很好地容忍.
科学领域:
- 心理药理学 心理药理学
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 强迫症 (OCD) 是一种普遍且令人虚弱的心理健康状况.
- 许多患有强迫症的患者对标准治疗,如选择性血清素再吸收抑制剂 (SSRI) 没有充分的反应.
- 初步研究表明,赛洛西宾是一种血清素受体激动剂,可能为强迫症提供治疗效益.
研究的目的:
- 研究psilocybin在治疗强迫症 (OCD) 的疗效和机制.
- 本分析特别报告了强迫症患者的西药理学挑战研究的临床结果.
主要方法:
- 患有中度至重度强迫症的参与者接受了两剂口服 псилоцибин (1mg,然后10mg) 四周间隔.
- 剂量发生在监控的日托中心,经验丰富的临床医生提供心理支持.
- 耶鲁-布朗强迫症强迫性尺度 (Y-BOCS) 是主要的结果衡量标准,在剂后四周内进行评估.
主要成果:
- 施用10毫克的 псилоцибин剂量在施用后一周显示了Y-BOCS得分的统计显著降低 (科恩d = 0.82,p = 0.002).
- 这种影响在Y-BOCS的强迫子表格上尤为明显 (科恩d = 0.74,p = 0.003).
- 观察到对强迫症症状的好处在三周内减少;没有注意到对抑郁症评级 (MADRS) 的显著影响.
结论:
- 口服10mg剂量的psilocybin似乎被很好地容忍,并且在强迫症症状管理中可能有效.
- псилоцибин在强迫症症状上表现出迅速发作的中度至大效应,持续时间长达一周.
- 对于强迫症和相关疾病,需要进行更多的随机化,安慰剂对照试验,使用多剂量psilocybin.
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