患者归因的延迟及其对乳腺癌两年生存率的影响:一个多中心前性队列研究
Desirée Martín-García1, Marilina García-Aranda1, Esperanza Varela-Moreno2
1Surgical Specialties, Biochemistry and Immunology Department, Faculty of Medicine, University of Málaga, 29010, Málaga, Spain; Red de Investigación en Cronicidad, Atención Primaria y Promoción de la Salud (RICAPPS), Madrid, Spain; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina - IBIMA Plataforma BIONAND, 29590, Málaga, Spain; Research and Innovation Unit. Hospital Universitario Costa del Sol, 29602, Marbella, Spain.
概括
乳腺癌诊断的延迟是患者造成的,这显著增加了死亡风险. 针对弱势群体 (如老年人和独自生活者) 的干预措施对于提高生存率至关重要.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 乳腺癌诊断和治疗的延迟受到患者人口统计学,临床因素和医疗保健系统性能的影响.
- 患者归因延迟 (PPAD) 是影响乳腺癌病例及时医疗和患者生存的重要因素.
研究的目的:
- 调查患者归因延迟 (PPAD) 对乳腺癌诊断和治疗的及时性的影响.
- 分析PPAD和乳腺癌患者生存结果之间的关联.
主要方法:
- 这是一项多中心的前性观察性研究,涉及543名2013年至2015年期间被诊断为乳腺癌的患者.
- PPAD被定义为从症状发作到初次医疗咨询的延迟超过90天.
- 统计分析包括分段和多变量分析,以确定PPAD和死亡率的预测因素.
主要成果:
- 总体PPAD的比率为14.18%.
- 单独生活被确定为PPAD的唯一独立预测因素 (OR: 1.882).
- PPAD是两年死亡率的独立风险因素 (OR 3.08),仅次于临床阶段 (OR 6.78). 年龄和其他因素也显示出与预后有显著关联.
结论:
- 有针对性的干预措施是必要的,以提高公众对癌症症状的认识.
- 解决弱势群体,包括老年人和独自生活的人群的障碍,对于减少诊断延迟至关重要.
- 减少延迟可以改善临床结果,增加生存率,提高患者的生活质量.
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