在移植中认知障碍评估:一篇综述
Safaa Azzouz1, Laurence Coté2, Donald Doell1
1Division of Geriatrics, Department of Medicine, McGill University, Montreal, QC, Canada.
Transplantation reviews (Orlando, Fla.)
|July 6, 2025
概括
认知障碍 (CI) 影响移植 (KT) 候选人和结果. 在KT候选人中标准化CI评估对于准确的评估和改善患者护理至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 神经心理学 神经心理学
- 移植医学 移植医学
背景情况:
- 轻度认知障碍 (CI) 在移植 (KT) 中存在挑战,尽管它不是绝对的禁忌.
- 目前在KT候选者中CI的临床评估方法缺乏标准化,导致实践困难.
研究的目的:
- 综合现有关于CI对成年移植接受者和候选人的影响的证据.
- 确定在评估CI对KT资格方面的挑战和知识差距.
主要方法:
- 从1333个标题和摘要中确定了观察性研究的系统审查.
- 包括7项研究,包括1035名KT受益者和4659名KT候选人.
- 分析认知评估工具的可变性 (例如,MoCA与MMSE) 以及其对报告的CI患病率的影响.
主要成果:
- 蒙特利尔认知评估 (38-55%) 与修改型迷你精神状态检查 (6-10%) 相比,报告了更高的CI患病率.
- CI与KT等候名单的可能性降低有关.
- 根据队列特征和评估工具,CI,KT,移植损失和死亡率之间的关联有所不同.
结论:
- 认知评估工具和值的变化限制了当前证据的含义.
- 需要进行额外的研究来标准化对KT候选人的CI评估.
- 全面的认知和功能评估对于准确的CI诊断,严重程度的确定和移植候选人的评估至关重要.
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