在接受免疫检查点抑制剂治疗的肺癌患者中患结核病的风险增加:一项回顾性多中心研究
Yeonhee Park1, Jinsoo Min2, Jeong Uk Lim3
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, yhpark@catholic.ac.kr.
概括
与化疗相比,肺癌免疫检查点抑制剂 (ICI) 治疗显著增加了结核病 (TB) 的风险. 早期结核病检测对于接受ICI治疗,出现新肺病变的患者至关重要.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 免疫检查点抑制剂 (ICI) 改善了肺癌存活率,但与结核病 (TB) 报告的增加有关.
- 在ICI治疗后结核病例的增加需要对这种关联进行调查.
研究的目的:
- 为了确定接受ICI治疗的肺癌患者患结核病的发病率是否比那些接受基化疗的患者更高.
主要方法:
- 一项回顾性研究分析了韩国八所大学医院的数据.
- 用ICI和基化疗治疗的肺癌患者之间结核病发生率的比较.
主要成果:
- 在ICI组,结核病发病率为每1000人/年4.46,而在白金组为1.12 (病率比:3.98).
- ICI治疗是唯一与结核病发生有显著关联的因素 (调整后危险比:3.701).
结论:
- 肺癌ICI治疗与结核病的风险显著增加有关.
- 建议对肺癌患者进行结核病的快速呼吸道样本检测,这些患者接受ICI治疗,患有新肺病变.
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