转录基因和神经递质洞察灰色物质的体积变化从1赫兹rTMS治疗精神分裂症与听觉口头幻觉
Yuanjun Xie1,2, Chenxi Li1, Muzhen Guan3
1Military Medical Psychology School, Fourth Military Medical University, Xi'an, China.
Acta psychiatrica Scandinavica
|July 6, 2025
概括
低频重复性横磁刺激 (rTMS) 通过增加灰质体积,降低了精神分裂症患者的听觉语言幻觉. 这些变化与神经可塑性基因表达和神经递质受体改变有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 听觉语言幻觉 (AVH) 是一种对标准治疗有抗性的精神分裂症的关键症状.
- 低频重复性横磁性刺激 (rTMS) 对AVH有希望,但机制尚不清楚.
研究的目的:
- 研究rTMS对精神分裂症中AVH的神经生物学影响.
- 探索灰质体积 (GMV),基因表达和神经递质受体的变化.
主要方法:
- 患有AVH的精神分裂症患者接受了积极的1HzrTMS,针对左侧关节 (TPJ) 或假刺激.
- 结构性MRI评估了治疗前后的GMV变化.
- 分析了GMV,基因表达和神经递质受体密度之间的关联.
主要成果:
- 活性rTMS显著降低了AVH症状,并在感官和认知处理区域增加了GMV.
- 与神经可塑性相关的基因组相关的结构变化.
- 观察到血清素,多巴胺和谷氨酸受体密度的显著变化,特定的基因和受体模式预测了GMV变化.
结论:
- 低频rTMS诱导有益的GMV变化,基因表达和神经递质受体变化在精神分裂症患者与AVH.
- 这些发现支持rTMS作为针对AVH神经生物学基础的有针对性的干预措施.
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