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甲基受体2抗体WRW4改善了小鼠糖尿病引起的认知衰退

Hiroki Uno1, Takahide Itokazu2, Toshihide Yamashita3

  • 1Department of Molecular Neurosciences, Graduate School of Medicine, Osaka University, Suita, Japan.

Neuroscience research
|July 6, 2025
PubMed
概括

甲基受体2 (FPR2) 通过激活微质细胞,有助于糖尿病相关的认知衰退. 用WRW4抑制FPR2改善了糖尿病小鼠的认知功能,并减少了微质变化.

关键词:
认知能力下降 认知能力下降糖尿病 糖尿病 糖尿病甲基受体2 甲基受体2微质细胞中的微质细胞

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Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
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