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Updated: Sep 16, 2025

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YAP-TEAD和PPAR之间的交叉方式抑制了HIV-1 LTR转录在体外

Chenliang Zhou1, Xiaolian Liu2, Hong He3

  • 1Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China; College of Pharmacy, Nanchang Medical College, Nanchang 330052, PR China.

Biochemical pharmacology
|July 6, 2025
PubMed
概括

是的相关蛋白 (YAP) 通过与NF-κB基因相互作用来负面调节HIV-1转录,这种基因由TEAD蛋白和过氧酶增殖器激活受体 (PPAR) 调节. 这一途径为HIV-1提供了新的治疗点.

关键词:
艾滋病毒-1 LTR通过NF-κB路径.这是一个PPAR.我们的 TEAD TEAD 团队.哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈

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