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环境因素影响山羊对PFOS和草甘的免疫反应:放牧和食之间的区别

Francesco Molinari¹, Gianluca Antonio Franco¹, Francesca Inferrera²

¹Department of Veterinary Sciences, University of Messina, Messina 98168, Italy.

Environmental toxicology and pharmacology

|July 6, 2025

概括

环境内分泌干扰物 (EDs),如PFOS和草甘影响山羊的免疫力. 免疫力受损的养山羊表现出对EDs的敏感性增加,突出了养系统在动物健康和食品安全方面的作用.

科学领域:

环境科学环境科学
免疫学免疫学免疫学
动物科学动物科学

背景情况:

化学内分泌干扰剂 (EDs) 污染了食物链,PFOS和草甘 (GLY) 已知会损害免疫力.
放牧环境提供多样化的饮食和微生物暴露,与食相比,可能会增强牲畜免疫系统.

研究的目的:

调查环境内分泌干扰物 (EDs) 与住房系统 (放牧与养) 之间的相互作用对山羊的免疫反应.
评估特定EDs,PFOS和GLY对山羊免疫细胞功能和细胞因子生产的影响.
了解住房系统如何调节EDS对牲畜免疫力的影响以及对食品安全的影响.

主要方法:

采用了一种ex vivo模型,使用来自放牧和养山羊的血液样本.
在暴露于EDs (PFOS和GLY) 后,分析了免疫细胞功能和细胞因子的产生.
测量了氧化应激标志物和炎症性细胞因子水平,以评估免疫反应.

主要成果:

养的山羊,表现出预先受损的免疫力,更容易受到PFOS和GLY的联合作用,显示出氧化应激增加.
牧场和食群体在炎症性细胞因子产生方面表现出类似的反应.
住房系统显著调节EDs对牲畜免疫力的影响.

结论:

住房系统在确定牲畜对内分泌干扰物的敏感性方面发挥着至关重要的作用.
通过受污染的食品,EDs对动物健康和人类健康构成潜在的风险.
需要进一步的研究,以了解长期ED对牲畜的影响,并制定缓解策略.

关键词:

内分泌干扰剂破坏内分泌的干扰剂免疫力是一种责任.

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