结构性大脑与童年抑制性情相关:一个ENIGMA-焦虑大分析
Janna Marie Bas-Hoogendam1, Rachel A Bernstein2, Brenda E Benson2
1Leiden University, Leiden, the Netherlands; Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands; National Institute of Mental Health, Bethesda, Maryland.
概括
在一项大型国际研究中,儿童抑制性情 (cIT) 与大脑结构没有显示一致的联系. 然而,家长/教师报告显示皮质厚度的性别特异性差异,特别是在状区域,这表明需要进一步研究.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 儿童抑制性情 (cIT) 是内化精神病理的一个危险因素.
- 关于cIT的神经成像研究是有限的,缺乏复制.
- 要了解cIT的神经基质,需要采用全面的全脑方法.
研究的目的:
- 通过大规模的大型分析来研究与cIT相关的结构性大脑特征.
- 检查cIT与皮层下体积,皮层厚度和表面积之间的关联.
- 在cIT和大脑结构之间的关系中识别潜在的性别和年龄相互作用.
主要方法:
- 汇集了来自国际研究场所的3,803名参与者 (6至25岁) 的结构性MRI数据.
- 在13岁之前使用气质评估 (行为观察,家长/老师报告,自我报告) 评估cIT.
- 采用超级分析,严格的图像处理和质量控制,用于全脑分析.
主要成果:
- 在完整样本中,没有发现cIT和大脑结构之间的总体关联.
- 在青少年和父母/教师报告中观察到与cIT在平均皮层厚度和右上顶厚度上的性别特异性相互作用.
- 探索性分析显示,海马体,骨和尾骨中可能存在发现,但大多数没有达到统计学意义.
结论:
- 这次大型分析没有发现cIT的结构性大脑相关性.
- 围区域在cIT中的作用需要进一步研究,特别是关于性别特异性的差异.
- 未来的研究应该探索大脑功能,并利用纵向设计来更好地理解cIT.
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