性差异和大规模大脑网络的年龄相关变化
Shujun Zhang1,2, Meiqin Li1,2, Anqiang Chen1,2
1Department of Radiology, Affiliated Hospital of Jining Medical University, No. 89 Guhuai Road, Jining, Shandong Province, 272000, China.
BMC medical imaging
|July 6, 2025
概括
男性表现出更强的网络间脑连接,而女性表现出增强的网络内连接. 年龄对女性互联网连接的影响更大,两种性别随着时间的推移都显示了网络内部连接的减少.
科学领域:
- 神经科学是一个神经科学.
- 脑部成像 脑部成像
- 人类神经生物学 人类神经生物学
背景情况:
- 以前的研究表明,大脑结构和功能的性别差异.
- 然而,大规模的大脑网络层面的性别和年龄差异尚未得到充分理解.
研究的目的:
- 为了研究大规模大脑网络连接的性别差异.
- 检查男性和女性大脑网络连接的与年龄相关的变化.
主要方法:
- 分析了436名健康成年人的休息状态功能性MRI数据.
- 独立组件分析确定了大规模的大脑网络.
- 多变量分析探讨了网络内部和网络内部功能连接 (FC) 的性别差异及其与年龄的关系.
主要成果:
- 男人表现出更强的网络间FC;女性在关键网络中表现出更强的网络内部FC.
- 与男性相比,女性在互联网FC中表现出与年龄相关的较大下降.
- 大多数网络内部FC在两性中随着年龄的增长而下降,除了一些例外.
结论:
- 男性通常具有更强的网络互联连接,女性具有更强的网络内部连接.
- 与年龄相关的互联网连接的下降在女性中更为明显.
- 这项研究提供了对性别和年龄依赖的大脑网络组织的见解.
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