包括NLR,AFR和SII在内的炎症标志物作为神经母细胞瘤的预后因素
Chenglong Zhang1, Xiaoyu Wang2, Yu Tian3
1General Surgery Department, Hebei Children's Hospital, Shijiazhuang, Hebei Province, China.
Scientific reports
|July 6, 2025
概括
系统性炎症标志物,包括中性粒细胞与淋巴细胞比率 (NLR) 和系统性免疫炎症指数 (SII),有效预测儿科神经母细胞瘤 (NB) 患者的死亡率和复发率,有助于预后评估.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症生物标志物 癌症生物标志物
- 炎症和癌症的作用
背景情况:
- 神经母细胞瘤 (NB) 是一种流行的儿科固体瘤,对高风险病例来说预后具有挑战性.
- 系统性炎症标记因其在各种恶性瘤中的预后意义而越来越受认可.
- 了解炎症在NB进展中的作用对于改善患者的治疗结果至关重要.
研究的目的:
- 在神经母细胞瘤 (NB) 中研究中性粒细胞与淋巴细胞比率 (NLR),全身免疫炎症指数 (SII) 和白蛋白与纤维素素比率 (AFR) 的预后值.
- 评估这些炎症标志物对NB患者死亡率和复发的预测能力.
主要方法:
- 对166名在2013年至2024年期间被诊断为NB患者的回顾性分析.
- 从手术前的血液参数计算NLR,SII和AFR.
- 利用ROC曲线,卡普兰-梅尔分析和考克斯回归来评估标记物的疗效.
主要成果:
- 在NLR和SII中,死亡率具有很高的预测值 (AUC为0.90和0.89).
- 高的NLR,低的AFR和高的SII与较差的整体存活率 (OS) 和无事件存活率 (EFS) 相相关.
- 在多变量分析中,NLR和SII被确定为OS和EFS的独立风险因素.
结论:
- 在评估NB时,NLR,SII和AFR具有显著的预后价值.
- 在预测神经母细胞瘤死亡率和复发风险方面,NLR和SII特别有效.
- 这些炎症标志物可以帮助NB患者的风险分层和治疗计划.
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