身体和精神活跃的生活方式与年轻的大脑和认知年龄有关
Niklas Behrenbruch1,2,3, Svenja Schwarck1,3, Beate Schumann-Werner1,3
1German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, Haus 64, 39120, Magdeburg, Germany.
GeroScience
|July 6, 2025
概括
健康的生活方式,包括低心血管风险的精神和身体活动,与更年轻的认知和大脑年龄有关. 这种组合支持大脑维护和认知性在老年人中.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 老龄化中的认知性对于维持生活质量至关重要.
- 了解生活方式,健康和认知/大脑衰老之间的相互作用是有限的.
- 与年龄相关的大脑病理,包括阿尔茨海默病,影响认知功能.
研究的目的:
- 研究生活方式和健康状况以及认知和大脑衰老之间的关系.
- 确定与成功的认知和大脑衰老相关的特定生活方式因素.
- 探索与生活方式相关的认知年龄差距 (CAG) 和大脑年龄差距 (BAG) 的概念.
主要方法:
- 对211名认知不受损的老年人进行深度表型化.
- 使用问卷,健身测试和血液数据来描述生活方式和健康状况.
- 认知年龄差距 (CAG) 和大脑年龄差距 (BAG) 的估计使用神经心理测试,血生物标志物 (pTau217,Aβ) 和MRI (白质强度过高,周血管空间,缩).
主要成果:
- 七个主要成分解释了49%的健康和生活方式差异.
- 具有较低心血管风险的精神和身体活跃的生活方式与明显较低的CAG和BAG相关.
- 活跃的生活方式和较低的CAG关联被BAG部分调解;APOE-ε4载体显示出更高的BAG.
结论:
- 低心血管风险,高精神参与度和高体力活动的结合生活方式与减少大脑病理和提高认知表现有关.
- 这种生活方式的特征支持大脑的维护和对抗衰老的认知弹性.
- 针对心理和身体活动以及心血管健康的生活方式干预措施可能会促进健康的认知衰老.
更多相关视频
05:04Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents
Published on: July 21, 2022
1.8K
10:19Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
Published on: August 22, 2014
14.4K
相关概念视频
01:30Cognitive Development During Adulthood
296
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
296
01:20Lifestyle Factors and Health
130
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
130
01:26Aging
191
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
191
01:19The Effect of Aging on Tissues
2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
213
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
213
01:20Exercise and Cardiovascular Response
1.1K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
1.1K