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肠道微生物群诱导的长非编码RNA Snhg9 调节人类恶性瘤的发展

Dengke Jia^1,2,3, Yaping He⁴, Qianle Chen^1,2,3

¹Second Clinical Medical College, Lanzhou University, Lanzhou 730000, China.

Current molecular medicine

|July 7, 2025

概括

肠道微生物和长非编码RNAs (lncRNAs) 影响癌症的进展. 具体来说,lncRNA Snhg9与肠道微生物群相互作用,影响人类恶性瘤,并提供潜在的治疗点.

科学领域:

在瘤学瘤学.
微生物学微生物学
分子生物学分子生物学

背景情况:

肠道微生物通过免疫和代谢途径调节癌症的发展.
长非编码RNAs (lncRNAs) 与癌症进展有关,并受到肠道微生物群的影响.
特定的lncRNA Snhg9与人类恶性瘤相关的肠道微生物相互作用.

研究的目的:

为了研究 lncRNAs 和癌症中的肠道菌群之间的复杂关系.
在人类恶性瘤的背景下阐明lncRNA Snhg9的调节机制.
根据lncRNA-微生物群相互作用,确定人类癌症的新型治疗点.

主要方法:

文献审查和对 lncRNAs,肠道微生物群和癌症现有研究的分析.
生物信息分析以确定Snhg9和微生物群落之间的交叉对话.
分子路径分析以了解Snhg9在瘤进展中的作用.

主要成果:

确立了 lncRNA Snhg9 和肠道微生物之间的显著交叉对话.
证明Snhg9参与各种人类恶性瘤的进展.
突出了肠道微生物对lncRNA表达和功能的免疫和代谢影响.

结论:

lncRNA Snhg9与肠道微生物群之间的相互作用是人类癌症发展的关键因素.
了解这些相互作用为开发新型癌症疗法提供了基础.
针对Snhg9-微生物群轴为未来的瘤学研究提供了一个有希望的途径.

关键词:

我们的肠道微生物组.在Snhg9的位置上.生物分子标记物.生物分子标记物.癌症癌症癌症癌症长非编码RNAs的编码.微RNAs 是一个微型RNA.监管监管监管监管监管监管

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