宫癌全身炎症反应指数的预后值:一个元分析
Xiaoxing Zhang1, Dongmei Ni1, Kai Zhu2
1Department of Gynecology and Obstetrics, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, China.
Future science OA
|July 7, 2025
概括
系统性炎症反应指数 (SIRI) 是宫癌 (CC) 结果不佳的重要预测指标. 升高的SIRI与CC患者的总生存率 (OS) 和无进展生存率 (PFS) 的降低有关.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 癌症预后 癌症预后
背景情况:
- 在宫癌 (CC) 中,全身炎症反应指数 (SIRI) 的预后价值一直受到争议.
- 准确的预后标记对于改善CC患者的治疗结果至关重要.
研究的目的:
- 进行元分析,准确确定SIRI在宫癌中的预后相关性.
- 评估SIRI与CC的总生存率 (OS) 和无进展生存率 (PFS) 之间的关联.
主要方法:
- 进行了一项元分析,结合了1271名患者的7项研究的数据.
- 使用95%置信区间 (CI) 的危险比率 (HR) 来评估SIRI对生存结果的影响.
主要成果:
- 在CC患者中,升高的SIRI与较差的OS (HR = 2.58) 和PFS (HR = 1.88) 有显著的关联.
- 较高的SIRI与先进的FIGO阶段 (OR = 1.71) 和高档组织学 (OR = 1.63) 相相关.
- SIRI没有与年龄,淋巴血管入侵,瘤大小,入侵深度,病理类型或淋巴结转移有显著关联.
结论:
- 较高的SIRI是宫癌中OS受损和PFS不良的重要指标.
- 升高的SIRI也与先进的FIGO阶段和CC中瘤差异化的差异相关,这表明它作为预后生物标志物的实用性.
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