慢性鼻炎和认知:一个系统的审查和元分析
Esther Yanxin Gao1,2,3, Benjamin Kye Jyn Tan2,3,4, Kai Lin Chan5
1Department of Otolaryngology-Head and Neck Surgery, Sengkang General Hospital, Singapore.
Rhinology
|July 7, 2025
概括
慢性鼻炎 (CRS) 与较差的认知功能有关. 然而,治疗CRS可能会提高处理速度和工作记忆,这表明对认知健康的潜在治疗联系.
科学领域:
- 神经科学是一个神经科学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 认知科学 认知科学
背景情况:
- 新兴的临床证据表明慢性鼻炎 (CRS) 和认知障碍之间存在联系.
- 假设局部和全身的神经炎症是将CRS与认知衰退联系起来的潜在机制.
研究的目的:
- 系统地评估慢性鼻炎 (CRS) 诊断与认知功能之间的关联.
- 研究CRS治疗对认知表现和痴呆风险的影响.
主要方法:
- 一项综合的分析,比较了CRS和没有CRS的患者的认知功能.
- 搜索了主要数据库 (PubMed,Embase,Scopus) 的相关研究,使用ROBINS-I/ROBINS-E评估偏差风险.
- 采用随机效应模型来综合认知得分和痴呆症患病率的数据.
主要成果:
- 包括107,610名参与者的10项研究,发现CRS与9%较差的全球认知功能有关.
- CRS治疗与处理速度 (8-9%) 和工作记忆的显著改善相关.
- 在横截面分析中,没有观察到CRS和痴呆症之间的显著关联.
结论:
- 慢性鼻炎对全球认知功能产生负面影响.
- 对CRS的治疗显示出增强特定认知领域的潜力,如处理速度和工作记忆.
- 建议进一步进行大规模的纵向研究,以充分理解CRS-认知关系.
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