低循环欧门丁-1,维生素D,抗氧化剂和微量元素在患有亚临床甲状腺功能低下症的妇女中的不平衡之间的关联
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Chiman H Sulaiman1, Lina Y Mohammed2, Mohammed A Hami1
1Chemistry Department, College of Science, University of Zakho, Zakho, Iraq.
Journal of the American Nutrition Association
|July 7, 2025
概括
妇女的亚临床甲状腺功能低下与低水平的奥门丁-1,维生素D和关键抗氧化剂有关. 这些缺陷,以及微量元素的不平衡,与这种情况有关.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 亚临床甲状腺功能低下症 (SCHT) 与改变的阿迪波金 (adipokine) 形状有关.
- 奥门丁-1是一种具有抗炎性能的阿迪波金,在SCHT病理生理学中具有潜在的作用.
- 在SCHT中,omentin-1,维生素D,抗氧化剂和微量元素之间的关系尚不清楚.
研究的目的:
- 研究新诊断SCHT的妇女中低循环的奥门丁-1水平与维生素D,抗氧化剂和微量元素的不平衡之间的联系.
- 探索omentin-1与甲状腺功能,维生素D,抗氧化剂和微量元素的相关性.
主要方法:
- 招募了50名新诊断的SCHT女性和40名健康女性.
- 测量包括甲状腺激素 (TSH,FT4,FT3),维生素D,奥门丁-1,抗氧化剂 (GST,SOD,CAT) 和微量元素 (Fe,Zn,Mg,Cu).
- 使用的检测方法包括电化学发光,光度测量,色度测量,光谱光度测量和ELISA.
主要成果:
- 与对照组相比,SCHT的妇女的奥门丁-1水平显著降低.
- SCHT组显示血清 (Zn), (Mg),超氧化失调酶 (SOD),谷氨-s转移酶 (GST) 和维生素D的减少.
- 在SCHT组中观察到铜/ (Cu/Zn) 和铜/ (Cu/Mg) 的比率增加.
- 奥门丁-1与酶 (CAT),SOD和维生素D正相关,与TSH负相关.
结论:
- 新诊断SCHT的妇女在奥门丁-1,抗氧化酶和微量元素中表现出显著的变化.
- 新诊断的SCHT中循环低的奥门丁-1与维生素D缺乏,抗氧化剂耗尽和微量元素失衡有关.
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