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综合战略对异性传播艾滋病毒感染者的死亡率的影响 - - 中国四川省梁山县,2008-2024年

Ruiying Liang^1,2, Fangfang Chen³, Yan Zhao¹

¹National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

China CDC weekly

|July 7, 2025

概括

一个全面的战略改善了人类免疫缺陷病毒 (HIV) 治疗覆盖率,并将死亡率降低了81.2%. 该模型为面临高艾滋病毒负担的资源有限环境提供了一个模板.

科学领域:

公共卫生公共卫生
流行病学流行病学
传染病管理传染病管理

背景情况:

梁山县的艾滋病毒流行带来了重大挑战.
实施了一项综合战略,以解决艾滋病毒检测,患者跟踪和抗逆转录病毒疗法 (ART) 在减轻贫困的努力.

研究的目的:

量化这一综合战略对艾滋病毒治疗覆盖率和死亡率的影响.
分析战略实施前后艾滋病毒治疗覆盖率和死亡率的趋势和变化.

主要方法:

利用中国艾滋病毒/艾滋病综合响应信息管理系统 (CRIMS) 数据库 (2008-2024) 的数据.
采用Cox比例危险模型来评估死亡风险因素和战略有效性.
应用中断时间序列分析来评估覆盖率和死亡率趋势的变化.
进行子组分析以确定不同种群之间的变化.

主要成果:

综合战略的结果是,艾滋病毒治疗覆盖率立即增加了21.62%,每年增加1.48%.
死亡率每年下降0.47%,与预期水平相比,到2024年将减少81.2%.
不接受ART是死亡的主要风险因素 (HR: 17.74).
在男性,关键县居民和在早期艾滋病毒感染阶段被诊断的个人中观察到最大的死亡率降低.

结论:

综合战略显著提高了艾滋病毒治疗覆盖率,并降低了梁山异性感染者死亡率.
进一步的干预措施应侧重于早期诊断,及时启动ART,并为晚期艾滋病毒疾病提供量身定制的支持.
梁山模式为高负担,资源有限的地区的艾滋病毒管理提供了一个可适应的框架.

关键词:

艾滋病艾滋病艾滋病是什么?抗逆转录病毒治疗 (ART)中断时间序列 (ITS)死亡率死亡率死亡率

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