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在患有库辛综合征的患者中治疗奥西洛德罗斯塔的管理:修改后的德尔菲共识小组
Susan L Samson1, Diane Donegan2, Eliza B Geer3
1Departments of Medicine and Neurologic Surgery, Mayo Clinic, Jacksonville, FL 32224, USA.
Journal of the Endocrine Society
|July 7, 2025
概括
专家内分泌学家制定了用于治疗库辛综合征 (CS) 的使用osilodrostat的指南. 这一共识提供了在临床实践中为最佳的患者准备,剂量和治疗奥西洛德罗斯塔的管理的建议.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 内源性库辛综合征 (CS) 涉及慢性暴露于过量的皮质醇.
- 手术是主要的治疗方法,但对于非手术候选人或持久性疾病而言,像奥西洛德罗斯塔特 (osilodrostat) 等医学疗法至关重要.
- 上腺类固醇生成抑制剂奥西洛德罗斯塔特已被批准用于CS,但需要个性化治疗指导.
研究的目的:
- 建立专家驱动的建议,以优化在治疗内源性库辛综合征时使用奥西洛德罗斯塔特.
- 解决关于在各种临床情景和患者群体中对利治疗的个性化治疗的知识差距.
主要方法:
- 一个经过修改的Delphi共识小组研究,涉及来自大量内分泌中心的13名专家.
- 三轮共识,包括两个匿名调查和一个虚拟研讨会,进行了10个月.
主要成果:
- 在26个关于使用奥西洛德罗斯塔特的陈述上达成共识.
- 主要主题包括患者准备,基线测试,剂量策略,剂量调整,监测和管理临床事件.
结论:
- 德尔菲方法产生了专家治疗指南和推对osilodrostat.
- 这些建议旨在教育医生,并优化对患有库辛综合征的患者的静止静止剂治疗.
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