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相关概念视频

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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RNA Editing02:23

RNA Editing

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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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RNA Interference01:23

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
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与酒精相关的肝病中的非编码RNA.

Ge Zeng1,2, Hui Gao2, Yanchao Jiang2

  • 1Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Liver research (Beijing, China)
|July 7, 2025
PubMed
概括

非编码RNAs (ncRNAs) 在与酒精有关的肝病 (ALD) 中至关重要. 失调的ncRNAs驱动肝损伤,炎症和纤维化,为ALD提供潜在的生物标志物和治疗点.

关键词:
与酒精有关的肝病 (ALD)生物标志物 生物标志物循环RNAs (循环RNAs) 是一种循环RNA.长非编码RNAs (lncRNAs) 是一种长非编码RNA.微RNAs (miRNAs) 是一种微型RNA.非编码RNAs (ncRNAs) 是一种非编码RNA.治疗目标 治疗目标

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科学领域:

  • 分子生物学分子生物学
  • 肝病学 肝病学是一种肝病学.
  • 遗传学 是一个遗传学.

背景情况:

  • 非编码RNAs (ncRNAs),包括microRNAs (miRNAs),长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs),调节基因表达.
  • 慢性饮酒会显著影响肝脏和血液循环中的ncRNA表达和功能.
  • 失调的ncRNAs与酒精相关性肝病 (ALD) 的病原发生有关.

研究的目的:

  • 提供关于ncRNAs在ALD中的作用的全面概述.
  • 阐明ncRNAs对ALD发展和进展的机制性贡献.
  • 讨论ncRNAs作为诊断生物标志物和ALD治疗点的潜力.

主要方法:

  • 在酒精相关性肝病中研究ncRNA的研究文献综述.
  • 对ncRNA参与肝细胞损伤,脂质代谢,炎症和肝星细胞激活等关键途径的分析.
  • 检查细胞外囊泡在ALD中ncRNA介导的细胞间通信中的作用.

主要成果:

  • ncRNAs关键调节与肝脏健康相关的基因表达和细胞功能.
  • 在ALD中中断的ncRNA表达会加剧肥胖症,炎症和纤维化.
  • 细胞外囊泡调解ncRNA通信,在ALD中放大肝损伤和纤维化.

结论:

  • 在ALD的发病和进展中,ncRNAs扮演着多方面的角色.
  • ncRNAs代表了ALD的有前途的诊断生物标志物.
  • ncRNAs作为ALD的治疗点具有显著的翻译潜力.