青少年药物治疗后的死亡率:从单个临床地点进行21年的随访
Christian Thurstone1,2, Cassandra Etzig1, Eileen Chen1
1Behavioral Health Services, Denver Health and Hospital Authority, Denver, CO, United States.
Frontiers in child and adolescent psychiatry
|July 7, 2025
概括
接受药物治疗的青少年的死亡率高于接受心理健康治疗的青少年. 出生时的男性性别和药物治疗参与预测五年内死亡风险增加.
科学领域:
- 青少年健康 青少年健康
- 公共卫生 公共卫生
- 药物使用障碍 药物使用障碍
背景情况:
- 青少年药物治疗后的死亡风险仍未得到充分研究.
- 了解高风险青年和死亡原因可以为干预提供信息.
- 青少年吸毒对健康构成重大风险.
研究的目的:
- 为了检查接受药物治疗的青少年的死亡率.
- 为了比较青少年药物治疗和心理健康治疗计划之间的死亡风险.
- 确定接受治疗的青少年死亡率的预测因素.
主要方法:
- 对2957名处于药物治疗中的青少年 (年龄10-19岁) 的回顾性图表审查.
- 与4400名接受心理健康治疗的青少年 (年龄10-19岁) 进行比较.
- 从2003-2024年使用公共卫生登记册和后勤回归分析死亡率数据.
主要成果:
- 接受药物治疗的青少年死亡率为4.0%,而接受心理健康治疗的青少年死亡率为2.1%.
- 药物治疗的原始死亡率为每100人年0.37,而精神健康治疗的0.19.
- 出生时的男性性别 (OR=2.10) 和药物治疗 (OR=3.02) 预测5年内死亡.
结论:
- 与接受心理健康治疗的青少年相比,接受药物治疗的青少年面临的死亡风险更高.
- 男性青少年和那些在药物治疗中的人有增加的死亡风险.
- 针对过量服用和其他死亡原因的干预措施对这一群体至关重要.
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