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综合生物信息学分析了童年喘中与热致死相关的基因和免疫透模式

Di Lian¹, Chenye Lin¹, Meiling Xie²

¹Pulmonology Department, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.

Frontiers in genetics

|July 7, 2025

概括

儿童喘涉及与热死相关的基因. BAX,BECN1,MAVS和BCL2显示出作为儿童喘诊断生物标志物的潜力,提供了新的治疗点.

科学领域:

基因组学就是基因组学.
免疫学免疫学免疫学
呼吸系统医学呼吸系统医学

背景情况:

儿童喘 (CA) 是一种普遍的慢性呼吸道疾病,全球发病率不断增加.
CA显著损害了儿童的呼吸功能,生活质量,并造成了相当大的负担.
了解CA的分子基础对于开发有效治疗方法至关重要.

研究的目的:

调查与热相关的差异表达基因 (PRDEGs) 在儿童喘病变中的作用.
通过生物信息学分析识别CA的潜在诊断生物标志物.
探索基于PRDEG参与的CA的新疗法目标.

主要方法:

利用生物信息学分析基因表达总量数据集用于儿童喘.
进行了差异性基因表达分析以识别PRDEGs.
进行了基因本体学,基因和基因组的京都百科全书和CIBERSORT分析,以获得功能和免疫细胞透洞察力.

主要成果:

确定了45个PRDEG,在免疫反应和炎症途径中进行丰富.
在CA患者的免疫细胞透中发现了显著的差异,包括增加的巨细胞M0和巨细胞.
BAX,BECN1,MAVS和BCL2被确定为具有CA诊断潜力的枢纽基因.

结论:

热症在儿童喘病原发生过程中起着重要作用.
BAX,BECN1,MAVS和BCL2作为CA的诊断生物标志物显示出希望.
向PRDEG可能为儿童喘管理提供新的治疗策略.

关键词:

生物标志物生物标志物儿童喘儿童喘儿童喘不同表达的基因 (DEGs)免疫透免疫透是什么?与热症相关的基因 (PRG)

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