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高密度脂蛋白胆固醇和多发性硬化症:一个系统性审查和元分析
Anastasios Makris1, Nikoletta Palli2, Angelos Liontos3
1School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
概括
与健康人相比,复发性缓解性多发性硬化症 (RRMS) 患者的高密度脂蛋白胆固醇 (HDL-C) 水平较低. 这一发现表明脂质概况,特别是HDL-C,对于评估RRMS疾病活性很重要.
科学领域:
- 神经学 神经学
- 代谢研究研究 代谢研究
背景情况:
- 多发性硬化症 (MS) 是一种慢性中枢神经系统炎症性疾病.
- 脂质代谢越来越多地被认为与MS临床结果有关.
研究的目的:
- 系统地调查高密度脂蛋白胆固醇 (HDL-C) 与多发性硬化症 (MS) 疾病活性之间的联系.
主要方法:
- 在PubMed,Cochrane图书馆和Clinicaltrials.gov.gov进行了系统的文献搜索.
- 对MS患者的HDL-C进行了前性和后性研究的定性综合和元分析.
- 分析了复发性复发性多发性硬化 (RRMS) 病例和健康对照 (HC) 之间的HDL-C平均差异.
主要成果:
- 分析了13项包括1692名参与者的研究 (859名RRMS,833名HC).
- 与HC相比,RRMS患者的HDL-C水平显著降低 (MD: -3.35 mg/dl,p = 0.005).与HC相比,RRMS患者的HDL-C水平明显降低 (MD: -3.35 mg/dl,p = 0.005).
- 在RRMS患者和HC患者中观察到较高的甘油三和总胆固醇水平,而低密度脂蛋白胆固醇没有显著差异.
结论:
- 高密度脂蛋白胆固醇 (HDL-C) 水平在复发性复发性多发性硬化症 (RRMS) 患者中明显降低,与健康对照人群相比.
- 脂质配置参数,包括HDL-C,在对RRMS患者的临床评估中需要考虑.
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