在慢性病患者中,饮食中的酸负荷与非胰岛素耐药性指标之间的关系
Hui Huang1,2, Qian Wang2, Ruimin Zhang2
1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in endocrinology
|July 7, 2025
概括
饮食中的酸负荷 (DAL) 与慢性病 (CKD) 患者的TyG-BMI和METS-IR等更高的胰岛素耐药性标志物有关. 这表明饮食对CKD的代谢健康有影响.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 胰岛素抵抗 (IR) 是慢性病 (CKD) 的一个重大问题.
- 非胰岛素基础的IR标记提供了替代的评估方法.
- 饮食中的酸负荷越来越多地被认为对其代谢的影响.
研究的目的:
- 调查非胰岛素基础的IR标志物与CKD患者的饮食酸负荷之间的关联.
- 评估特定的IR指数 (TyG,TyG-BMI,TG/HDL-C,METS-IR) 与饮食中的酸性负荷 (DAL) 之间的关系.
主要方法:
- 该研究包括288名CKD患者.
- 使用TyG,TyG-BMI,TG/HDL-C比率以及METS-IR进行评估的IR.
- 使用潜在脏酸负荷 (PRAL),内源性净酸产量 (NEAP) 和食酸负荷 (DAL) 的量化食酸负荷.
- 采用多重线性回归分析,对混因素进行调整.
主要成果:
- 饮食酸负荷 (DAL) 与TyG-BMI (r=0.251,P<0.001) 和METS-IR (r=0.274,P<0.001) 有显著的正相关性.
- 在调整了混因素 (年龄,性别,HTN,糖尿病,eGFR) 之后,DAL仍然与TyG-BMI (β=0.336,P=0.008) 和METS-IR (β=0.091,P=0.007) 有意义地相关.
- 具有较高DAL分数的患者表现出更高水平的IR标志物.
结论:
- 饮食中的酸负荷与CKD患者的关键胰岛素抵抗标志物有积极的关联.
- 饮食中较高的酸含量可能会导致CKD患者的代谢功能障碍增加.
- 这些发现强调了饮食管理在缓解CKD中IR方面的潜在作用.
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