互白蛋白作为阻塞性睡眠呼吸暂停和细胞癌之间的潜在联系
Katarzyna Stańska-Kowalik1, Kamila Maliszewska-Olejniczak2, Michał Fiedorowicz3
1Department of Otorhinolaryngology, Hospital in Sanok, Sanok, Poland.
概括
阻塞性睡眠呼吸暂停 (OSA) 和细胞癌 (RCC) 具有共同的炎症过程. 在OSA患者中增加的促癌细胞因子表明与RCC风险和预后存在联系,OSA治疗可能具有治疗意义.
科学领域:
- 在瘤学瘤学.
- 睡眠医学 睡眠医学
- 免疫学 免疫学 免疫学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 和细胞癌 (RCC) 涉及共同的炎症途径.
- 越来越多地认识到OSA和RCC风险/预后之间的剂量依赖关系.
- 连接OSA和RCC的潜在机制仍然不清楚.
研究的目的:
- 审查现有的文献,并确定患有OSA和RCC的患者的常见细胞因子概况.
- 探索OSA相关炎症和RCC病原体之间的潜在联系.
- 研究OSA治疗对与癌症相关的细胞因子的治疗影响.
主要方法:
- 在PubMed数据库的系统文献搜索.
- 包括儿童和成人OSA和RCC患者中细胞因子水平的英语研究.
- 不包括动物和体外试验研究.
主要成果:
- 66篇文章被选中进行分析.
- 在OSA研究中,研究了20种不同的互白蛋白.
- 与对照组相比,在OSA患者中观察到关键的促癌细胞因子 (IL-1,IL-4,IL-6,IL-8,IL-17,IL-18,IL-23,IL-33) 的水平升高.
结论:
- 在OSA和RCC患者之间存在大量的细胞因子概况重叠.
- 在OSA患者中增加的促癌性互白蛋白可能表明与RCC预后的联系.
- 对OSA的持续正气道压力 (CPAP) 治疗减少了促癌细胞因子,这表明OSA的RCC患者的治疗潜力.
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