在体内评估呼吸道壁在吸入伤害反应期间的合规性,使用解剖学光学连贯弹性学
Yinghan Xu1, Srikamal Soundararajan2, Scott H Randell3
1University of North Carolina at Chapel Hill, Department of Biomedical Engineering, Chapel Hill, North Carolina, United States.
通过解剖光学连贯性断层扫描 (aOCT) 测量的正常化横截面合规性 (nCsC) 显示了量化气管吸入损伤严重性的潜力. 这种新的指标提供了比目前的主观方法更客观的评估.
科学领域:
- 生物医学工程 生物医学工程
- 呼吸系统医学 呼吸系统医学
- 医疗成像医学成像
背景情况:
- 吸入伤害是烧伤的严重并发症,导致严重的发病率和死亡率.
- 目前的吸入伤害诊断方法缺乏定量指标,是主观的.
- 准确的诊断对于有效的治疗和改善患者结果至关重要.
研究的目的:
- 开发和验证标准化横截面合规性 (nCsC) 作为气管吸入损伤严重性的定量衡量.
- 评估解剖光学连贯性断层扫描 (aOCT) 在体内测量nCsC的实用性.
- 为了将nCsC与损伤严重程度和解剖位置相关联.
主要方法:
- 在猪身上使用了一种定制的aOCT系统,配有内压力探针.
- 蒸汽诱导的各种强度的吸入伤害被创造出来.
- 在受伤后长达6小时内,从头到喉测量了nCsC,随后进行了组织学分析.
主要成果:
- 空气道壁的nCsC最初在受伤后降低,在4小时后观察到恢复.
- ANOVA证实了时间对nCsC的显著影响 (p=0.002).
- nCsC与解剖学位置负相关,而组织学损伤等级与位置正相关,表明更接近蒸汽源的损伤较高.
结论:
- 气道壁 nCsC 是一个有前途的定量生物标志物,用于评估吸入伤害.
- 基于aOCT的nCsC测量提供了一个客观的方法来评估损伤严重程度.
- 这项技术有可能提高人类吸入伤害的临床管理.
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