对患有意识障碍的儿童进行高压氧气治疗的预后风险因素的分析
Long Zhao1, Sha Li1, Yansong Liu1
1The Second Department of Rehabilitation, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, People's Republic of China.
Journal of multidisciplinary healthcare
|July 7, 2025
概括
早期的高压氧疗法 (HBOT) 和更好的基线神经学评分可以改善有意识障碍 (DOC) 的儿童的预后. 识别风险因素可以优化治疗和神经系统的结果.
科学领域:
- 儿科神经学 儿科神经学
- 高压医学的高压医学.
- 神经康复疗法 神经康复疗法
背景情况:
- 儿童的意识障碍 (DOC) 存在重大治疗挑战.
- 高压氧气疗法 (HBOT) 显示出改善儿童DOC中大脑氧化和神经修复的前景.
- 儿科DOC中HBOT结果的预后因素尚未得到很好的定义.
研究的目的:
- 确定影响经过HBOT的DOC儿童预后的风险因素.
- 分析与接受HBOT的儿科DOC患者的不良结果相关的因素.
主要方法:
- 对255名用HBOT治疗的DOC儿童的回顾性分析 (2010年1月至2024年1月).
- 收集的数据包括人口统计,病因,格拉斯哥昏迷表 (GCS),昏迷恢复表修订 (CRS-R),治疗时间和并发症.
- 后勤回归识别了基于格拉斯哥结果尺度 (GOS) 的不良预后的独立风险因素.
主要成果:
- 预后不佳的危险因素包括年龄<12岁,晚期HBOT时间,HBOT频率低,HBOT前GCS和CRS-R得分低,以及缺氧缺血性脑病变.
- 具体的独立风险因素因病因而有所不同:创伤性脑损伤的低GCS,脑炎的低CRS-R,以及 hypoxic-ischemic encephalopathy 的晚期HBOT时间/低频率/低CRS-R.
结论:
- 早期的HBOT干预对于改善儿科DOC的结果至关重要.
- 基线神经状态 (GCS,CRS-R) 显著预测康复.
- 了解这些风险因素有助于优化HBOT治疗策略,并改善DOC儿童的长期神经结果.
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