预防性特兰胺酸在为威尔姆斯瘤进行开放性腎切除术的儿童减少血流的有效性:一项随机对照研究
Sateesh Verma1, Shraddha Agarwal1, Prem R Singh1
1Department of Anaesthesiology and Critical Care, King George's Medical University, Lucknow, IND.
Cureus
|July 7, 2025
概括
特兰胺酸 (TXA) 显著降低了为威尔姆斯瘤而接受腎切除术的儿童的手术内流血和红细胞输血需求. 这项研究证实了TXA的存在.
科学领域:
- 儿科瘤学 儿科瘤学
- 手术性静血 静血是指手术性静血
- 药理学 药理学是指药理学的学科.
背景情况:
- 威尔姆斯瘤瘤切除术经常涉及大量的手术内出血.
- 特兰胺酸 (TXA) 是一种经过验证的抗纤维解质剂,用于减少各种手术过程中的手术失血.
- 它在儿科威尔姆斯瘤手术中的有效性需要具体的调查.
研究的目的:
- 为了评估静脉注射的三胺酸 (TXA) 在儿童维尔姆斯瘤瘤切除术期间最大限度地减少手术内流血的有效性.
- 评估二次结果,包括包装红细胞 (PRBC) 输血要求和手术内血液动力学稳定性.
主要方法:
- 一项随机对照试验,涉及60名为威尔姆斯瘤进行脏切除术的儿科患者.
- 干预组接受了静脉注射TXA (充满剂量和输液),而对照组接受了正常的盐水.
- 在手术期间流失的血液,PRBC输血量和血液动力学参数都被仔细监测.
主要成果:
- 在TXA组显著降低了手术内流血量 (216.33毫升与306.33毫升相比; p=0.001).
- 在TXA组中,平均PRBC输血量也显著减少 (167.0毫升 vs 199.8毫升; p=0.045).
- 在手术后的TXA组中观察到较低的血清乳酸水平 (1.82 mmol/L vs 2.63 mmol/L; p=0.001),具有类似的血液动力学概况.
结论:
- 静脉注射TXA是一种安全有效的补充剂,用于减少维尔姆斯瘤儿科腎切除术中的手术内流失血液.
- 在这种患者群体中,TXA的使用可以减少对PRBC输血的需要.
- 进一步的研究可能会探索最佳剂量和长期结果.
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