卡菲尔佐米布诱导的血栓小血管病变:一个罕见并发症的病例报告
Manogna Pendyala1, Ayesha Tahir1, Purnoor Kaur1
1Department of Internal Medicine, Mercy Health - St. Vincent Medical Center, Toledo, USA.
Cureus
|July 7, 2025
概括
血栓性微血管病变 (TMA) 是治疗多发性骨髓瘤的卡菲尔佐米布治疗的罕见但严重的副作用. 早期诊断和用等离子体和血液透析治疗可以导致临床改善.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 血栓性微血管病 (TMA) 是一种由微血管病性血液溶解性贫血,血栓细胞衰竭和微血管血栓症引起的器官损伤所表现的疾病.
- 药物诱导的TMA是一个诊断挑战,因为缺乏特定的测试来识别致病原体.
- 几种化疗剂与TMA有关,而卡菲尔佐米布是较不常见的原因.
相关概念视频
Types of Intermediate Filaments
3.8K
The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...
3.8K
Clot Retraction and Fibrinolysis
6.9K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.9K
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
41
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
41


