对饮食及其与儿科性结肠炎疾病活性相关性的定量和定性评估
Víctor Manuel Navas-López1, Marta Herrador-López1, Encarnación Torcuato-Rubio1
1Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario, Málaga, Spain.
Journal of pediatric gastroenterology and nutrition
|July 7, 2025
概括
饮食质量影响儿科性结肠炎 (UC) 的结果. 最少加工的食物促进缓解,而超加工的食物加剧炎症,建议在UC管理中整合饮食.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 儿科炎症性肠病 儿科炎症性肠病
背景情况:
- 性结肠炎 (UC) 是一个日益严重的全球健康问题,特别是在发展中国家.
- 饮食对UC病原和临床结果的影响,特别是在儿科患者群体中,需要进一步阐明.
- 了解与疾病活动相关的饮食模式对于优化患者管理至关重要.
研究的目的:
- 调查儿科UC患者的饮食摄入量和习惯.
- 评估饮食模式与临床缓解 (CR) 和粘膜愈合 (MH) 之间的关联.
- 确定预测儿科UC治疗反应的饮食因素.
主要方法:
- 在西班牙一家医院对47名儿科UC患者 (8-18岁) 进行了横截面研究.
- 使用3天食物日记,问卷和NOVA分类进行饮食评估.
- K-意味着对饮食模式进行聚类;物流回归,随机森林和梯度增强用于预测建模.
主要成果:
- 实现CR和MH的患者 (集群1) 显示未加工食品,纤维和微量营养素的摄入量较高 (p<0.05).
- 没有CR/MH的患者 (集群3) 摄入了更多的超加工食品 (UPF) 和和脂肪 (p<0.01).
- 无论药物治疗如何,UPF摄入量和饮食质量不佳都独立预测了更糟糕的结果.
结论:
- 饮食质量与儿童的UC疾病活性和治疗反应有显著的关联.
- 摄入少量加工食品和微量营养素的较高摄入量与更好的结果相关.
- 增加的UPF消费与持续的UC炎症有关,这强调了UC管理中需要进行饮食干预的需要.
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