一个可解释的连接体卷积变压器用于多模态自闭症谱系障碍分类
Reza Nazari1, Mostafa Salehi1, Afshin Shoeibi2
1School of Intelligent System, College of Interdisciplinary Science and Technologies, University of Tehran, Tehran, Iran.
International journal of neural systems
|July 7, 2025
概括
这项研究介绍了Connectome卷积变压器 (CCTF),这是一个新的深度学习工具,用于使用脑成像来诊断自闭症谱系障碍 (ASD). 通过整合多式联网大脑连接数据,CCTF准确地识别了ASD生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 人工智能的人工智能
- 医学诊断 医学诊断 医学诊断
背景情况:
- 自闭症谱系障碍 (ASD) 诊断由于异质性和漫长的行为评估而具有挑战性.
- 自动神经成像工具显示出希望,但与多站点数据变异性作斗争.
- 整合功能磁共振成像 (fMRI) 和结构磁共振成像 (sMRI) 数据是复杂的.
研究的目的:
- 开发一个多式联机深度学习框架,Connectome卷积变压器 (CCTF),用于准确的ASD诊断.
- 从fMRI和sMRI数据中整合功能和结构性大脑连接.
- 通过结合各种连接指标和形态属性来增强特征表示.
主要方法:
- 开发了Connectome卷积变压器 (CCTF),这是一个多式联网深度学习框架.
- 来自fMRI的综合功能连接度量和来自sMRI的结构共变性网络.
- 利用连接组卷积嵌入模块,变压器编码器和节点到图汇集用于生物标记物识别.
主要成果:
- 在多个站点的ABIDE数据集上,CCTF的性能超过了最先进的方法.
- 实现了高精度:[公式:见文本] (fMRI),[公式:见文本] (sMRI) 和[公式:见文本] (fMRI+sMRI组合) 在内部验证中.
- 在网站间交叉验证中证明了稳定性和可通用性[公式:参见文本]的准确性.
结论:
- CCTF框架为使用多式神经成像的自动自闭症诊断提供了一个强大的和可通用的方法.
- 确定的大脑区域与已知的ASD神经生物学保持一致,这表明进一步了解这种疾病的潜力.
- 在克服基于神经成像诊断的多站点数据集成挑战方面,CCTF显示出前景.
相关概念视频
Autism Spectrum Disorder
344
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
344
Classification of Neurotransmitters
3.6K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
3.6K
Modeling in Therapy
152
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
152
Neural Circuits
1.6K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.6K
Classification of Connective Tissues
11.7K
The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....
11.7K
Classification of Systems-I
318
Linearity is a system property characterized by a direct input-output relationship, combining homogeneity and additivity.
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
318

