自我报告的人类免疫缺陷病毒成年人的日常功能:与全球神经认知功能和抑郁症状的纵向关联
Maximo R Prescott1,2, Emily W Paolillo3, Carlos D Rivera Saldana1
1Department of Psychiatry, UC San Diego, San Diego, CA, USA.
概括
在艾滋病毒感染者 (PWH) 中,认知功能会影响日常生活,但严重的抑郁症会取代这种联系. 高抑郁症症状导致报告的日常功能下降,无论认知能力如何.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 传染性疾病 传染性疾病
背景情况:
- 诊断与艾滋病毒相关的神经认知障碍 (HAND) 需要将损伤与艾滋病毒联系起来. 抑郁症状可能会影响艾滋病毒 (PWH) 感染者的自我报告功能.
- 了解认知,抑郁和日常功能之间的相互作用对于管理HAND和改善PWH生活质量至关重要.
研究的目的:
- 检查客观的全球认知,抑郁症状严重程度和PWH中自我报告的日常功能之间的纵向关系.
- 确定抑郁症状的严重程度是否会影响认知表现和PWH中的功能下降之间的关联.
主要方法:
- 分析了894个PWH的纵向数据,使用多层次建模.
- 收集了日常生活工具活动 (IADL) 依赖和主观认知困难的自我报告措施,以及抑郁症状严重程度 (BDI-II).
主要成果:
- 在IADL依赖的全球认知和平均抑郁症严重程度之间发现了显著的相互作用. 更糟糕的认知与更大的IADL依赖有关,特别是在那些抑郁症状较低的人群中.
- 更高的抑郁症状严重程度与更高的IADL依赖的可能性有关,无论认知表现如何.
- 没有观察到全球认知和抑郁症状严重程度与主观认知困难之间的显著相互作用.
结论:
- 认知能力与低至中度抑郁症状的PWH中IADL依赖性有关.
- 患有高抑郁症症状严重程度的个体报告IADL依赖,无论他们的认知状态如何.
- 这些发现强调了自我报告的功能和抑郁症对PWH日常生活的深刻影响的临床意义.
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