儿童肥胖症中的塞斯特林-2水平和胰岛素耐药性
Pembe Soylu Ustkoyuncu1, Derya Kocer2
1Pediatric Nutrition and Metabolism Clinic, Kayseri City Training and Research Hospital, Health Sciences University, Kayseri, Turkey.
概括
患有胰岛素耐药性的肥胖儿童显示抗氧化蛋白Sestrin-2的水平升高. 这一发现突出了Sestrin-2的存在.
科学领域:
- 儿科 儿科 儿科
- 代谢障碍 代谢障碍 代谢障碍
- 氧化压力是一种氧化压力.
背景情况:
- 肥胖是一个与代谢障碍相关的全球健康问题.
- 氧化应激和氧化剂-抗氧化剂失衡有助于内脏脂肪的积累.
- 塞斯特林-2是一种由氧化应激诱导的抗氧化蛋白,提供细胞保护.
研究的目的:
- 为了研究肥胖儿童的Sestrin-2水平,有或没有胰岛素抵抗.
- 在研究小组中比较代谢和炎症标志物.
主要方法:
- 研究包括30名患有胰岛素抵抗的肥胖儿童,29名没有胰岛素抵抗的肥胖儿童 (BMI Z-score > 2) 和30名健康对照.
- 胰岛素耐药性被定义为胰岛素耐药性 (HOMA-IR) 价值高于3.16.6的恒温模式评估.
- 分析了塞斯特林-2水平和常规实验室检测.
主要成果:
- 与对照组相比,患有胰岛素耐药性的肥胖儿童的BMI,胰岛素,HOMA-IR,ALT,总胆固醇,LDL,甘油三,C反应蛋白,腰围,静脉血压,腹静脉血压,白细胞计数和尿酸水平明显较高.
- 与对照组相比,肥胖组的C-反应蛋白,透气血压和尿酸都增加了.
- 在胰岛素耐药的肥胖儿童中,塞斯特林-2水平显著升高.
结论:
- 在患有胰岛素耐药性的肥胖儿童中,Sestrin-2的水平升高.
- 这些发现表明Sestrin-2在儿童肥胖相关的代谢功能障碍中可能发挥作用.
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