在长期COVID患者中,超过6个月的身体残疾轨迹
Imane Salmam1,2, François Desmeules3,4, Kadija Perreault1,2
1Center for Interdisciplinary Research in Rehabilitation and Social Integration (Cirris), CIUSSS Capitale-Nationale, Quebec City, QC, G1M 2S8, Canada.
长期的COVID显著损害了身体功能和生活质量,疲劳和低的每日步数预测了较差的结果. 早期识别这些预测因素对于有效的长期COVID管理和康复至关重要.
科学领域:
- 康复医学 康复医学 康复医学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 长期COVID对身体功能和与健康相关的生活质量 (HRQoL) 的持续影响需要了解临床指导.
- 评估长期影响对于制定有效的康复策略至关重要.
研究的目的:
- 为了比较长期COVID (LCG) 的成年人与短期COVID (SCG) 或没有COVID-19 (CG) 的成年人的身体能力和HRQoL.
- 在长期COVID组中确定6个月HRQoL的基线预测因素.
主要方法:
- 展望纵向队列研究,涉及360名成年人 (每组120名:CG,SCG,LCG).
- 在实验室的评估包括握力,短物理性能电池 (SPPB),6分钟步行测试 (6MWT) 和自我报告的结果 (HRQoL,疲劳,睡眠).
- 健身追踪器记录了日常活动;使用了通用估计方程和递归分区分析.
主要成果:
- 对于HRQoL,疲劳,SPPB和6MWT发现了显著的时间 × 组相互作用,LCG显示改善,但只有疲劳达到临床意义.
- 与CG和SCG相比,LCG在大多数结局上得分始终较低,这表明持续的损害.
- 基线疲劳和每日步数预测了LCG的6个月HRQoL.
结论:
- 长期患有COVID的成年人经历了持续的身体和功能障碍.
- 识别疲劳和活动水平等早期预测因素对于定制治疗和预测患者长期需求至关重要.
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