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在一个日本队列的计算机辅助诊断系统的外部验证,旨在在多参数核磁共振 (MRI) 中描述ISUP≥2个前列腺癌

Raphael Escande¹, Tristan Jaouen², Christelle Gonindard-Melodelima^3,4

¹Department of Radiology, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.

International journal of urology : official journal of the Japanese Urological Association

|July 7, 2025

概括

一个计算机辅助诊断 (CADx) 系统在MRI上检测前列腺癌方面表现出良好的概括性. 然而,其预定义的值导致日本队列的敏感性较低,比法国培训数据更高的特异性.

科学领域:

放射学放射学是一门学科.
在瘤学瘤学.
医疗成像医学成像

背景情况:

前列腺癌的诊断依赖于多参数MRI (mpMRI).
计算机辅助诊断 (CADx) 系统可以帮助解释mpMRI发现.
在不同人群中CADx系统的通用性对于临床采用至关重要.

研究的目的:

评估在法国数据上训练的CADx系统在日本患者队列中诊断临床显著的前列腺癌 (国际泌尿病学学会等级≥2) 的通用性.
在mpMRI上使用表面扩散系数 (ADC) 和洗进速率参数来评估CADx系统的性能.

主要方法:

对68名经过激进前列腺切除术的日本患者的回顾性分析.
经验丰富的放射科医生进行mpMRI分析,并分配前列腺成像报告和数据系统版本2.1 (PI-RADSv2.1) 评分.
从划分的兴趣区域计算CADx分数.
使用ROC分析对CADx和PI-RADSv2.1得分与整体前列腺切除样本进行比较.

主要成果:

在外围区域 (PZ),CADx和PI-RADSv2.1得分显示,接收器运行特征曲线 (AUC) 的80%以下的区域相似.
在过渡区 (TZ),PI-RADSv2.1 (93%) 的表现优于CADx (79%),尽管表现不显著 (p=0.051).
来自法国队列的CADx值在日本队列中产生了较低的灵敏度 (PZ:60%,TZ:42%) 和较高的特异性 (PZ:95%,TZ:92%),可能是由于ADC值和MRI获取的差异.

结论:

在外部日本队列中,CADx系统的整体表现良好.
从培训队列中得出的预定义的诊断值导致验证队列的敏感性降低和特异性增加.
对于不同种群和成像协议,可能需要进一步优化CADx值.

关键词:

这就是为什么MRI是MRI.人工智能的人工智能是人工智能.前列腺癌是前列腺癌.进行激进的前列腺切除术.

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