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长期泌尿功能障碍和对直肠癌手术后生活质量的影响:一个前性的多中心观察性研究
Kohei Ueno1, Nobuaki Hoshino1, Koya Hida1
1Department of Surgery, Kyoto University Hospital, Kyoto, Japan.
Journal of surgical oncology
|July 7, 2025
概括
结直肠癌手术可能导致持续的尿路功能障碍 (UD) 影响生活质量 (QoL),特别是在IPSS和ICIQ-SF评估时,尽管尿液残留量 (RUV) 得到改善.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 手术瘤学手术瘤学
- 患者的治疗结果.
背景情况:
- 直肠癌手术可能导致长期的尿路功能障碍 (UD).
- 经过验证的评估,如残留尿量 (RUV),国际前列腺症状评分 (IPSS) 和国际商失禁问卷-简短表格 (ICIQ-SF) 用于评估UD.
- 生命质量 (QoL) 是手术后的关键结果衡量标准.
研究的目的:
- 为了研究直肠癌手术后尿路功能障碍 (UD) 的长期变化.
- 用验证的问卷来评估 UD 对生活质量 (QoL) 的影响.
- 为了比较UD评估的不同方法后直肠癌手术.
主要方法:
- 一项前性多中心观察性研究包括103名接受直肠癌切除术的患者.
- 尿功能障碍 (UD) 在基线和6,12和24个月的术后被评估,使用RUV,IPSS和ICIQ-SF.
- 通过使用EORTC QLQ-C30问卷来评估生活质量 (QoL).
主要成果:
- 基于RUV的UD患者比例在24个月内从19.3%显著下降到7.6% (p=0.022).
- 基于IPSS的UD保持稳定 (33.4%至29.0%,p=0.398),而基于ICIQ-SF的UD显著增加,从17.5%至29.0% (p=0.019).
- 患有UD的患者 (IPSS和ICIQ-SF) 在24个月后报告了显著较低的QoL得分,与RUV定义的UD患者不同.
结论:
- 余尿量 (RUV) 值在术后有所改善,对长期生活质量 (QoL) 的影响有限.
- 用IPSS和ICIQ-SF测量的尿功能障碍 (UD) 在直肠癌手术后持续存在.
- 持续性UD,特别是当IPSS和ICIQ-SF显示时,会对因直肠癌治疗的患者的长期QoL产生负面影响.
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