肝硬化患者尿道微生物群中的微生物失生症
Johannes Woltsche1, Christian Pacher-Deutsch2,3, Stefan Fürst2
1Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
The American journal of gastroenterology
|July 7, 2025
概括
肝硬化患者的尿路微生物组发生了变化,多样性减少,Streptococcus减少. 这可能解释了他们患尿路感染的风险增加.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 胃肠病学 胃肠病学
背景情况:
- 肝硬化与身体各部位的微生物组变化有关,包括皮肤,唾液和血清.
- 肝硬化患者面临患上尿路感染 (UTI) 的风险更高.
研究的目的:
- 为了研究诊断为肝硬化患者的尿路微生物组合.
- 探索尿路微生物组变化与肝硬化中尿路感染易感性之间的潜在联系.
主要方法:
- 使用16S rRNA测序对137名患者的中期尿样进行分析.
- 包括68名肝硬化患者和32名非肝硬化患者作为对照.
主要成果:
- 肝硬化患者在他们的尿路微生物群中显著减少了α-多样性.
- 对照个体的尿道微生物组显示了在Streptococcus物种中显著的丰富.
结论:
- 尿路微生物多样性的减少和肝硬化患者中 estreptococcus 的少量可能导致他们对尿路感染的易感性增加.
- 这些发现突显出尿路微生物组是肝硬化中尿路感染发展的潜在因素.
相关概念视频
Urinary Tract Infection II: Pathophysiology
52
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
52
Urine Studies II: Urine Culture and Sensitivity Test
128
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
128
Urinary Tract Infection I: Introduction
54
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
54
Urine Studies I: Urinalysis
166
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
166
Fungal Phylum Microsporidia
127
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
127
Disorders of the Urinary System
489
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
489


