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转移性分化甲状腺癌患者的死亡原因

Q Liu¹, B Ma², M Song¹

¹Department of Thyroid Surgery, The First Hospital of China Medical University, 155 Nanjing North Street, Shenyang, 110001, Liaoning, China.

Journal of endocrinological investigation

|July 7, 2025

概括

转移性分化甲状腺癌 (mDTC) 患者因非癌症原因,包括脑血管疾病,面临显著的死亡率. 改善对mDTC幸存者的管理和后续行动对于解决这些风险至关重要.

科学领域:

在瘤学瘤学.
流行病学流行病学
公共卫生公共卫生

背景情况:

转移性差异化甲状腺癌 (mDTC) 是死亡的重要原因,尽管差异化甲状腺癌 (DTC) 治疗的进展.
有限的数据存在于mDTC患者的特定死亡原因.
了解死亡率因素对于改善患者的治疗结果至关重要.

研究的目的:

调查转移性分化甲状腺癌 (mDTC) 患者的死亡原因.
分析甲状腺癌,随后的癌症和mDTC患者的非癌症原因的死亡率.
确定有助于mDTC死亡率的特定风险因素.

主要方法:

利用监测,流行病学和最终结果 (SEER) 数据库 (2000-2020年) 来识别187747个DTC病例中的4749个mDTC病例.
估计甲状腺癌,随后的癌症和非癌症原因的累积死亡率.
职业标准化死亡率 (SMR) 用于比较观察到的和预期的死亡率.

主要成果:

在mDTC队列中,43.1%的患者死亡,5年累积死亡率最高的是大脑 (53.1%) 和肝脏 (49.0%) 转移.
随后的癌症,主要是肺癌,导致7.1%的mDTC死亡.
脑血管疾病是主要的非癌症死亡原因 (SMR,1.45).

结论:

非癌症死亡率是mDTC患者死亡的重要原因之一,而且在不断增加.
对于mDTC幸存者来说,个性化治疗和后续计划至关重要.
对未来的健康风险的全面指导是必要的mDTC管理.

关键词:

死亡原因死亡原因观察性研究是一种观察性研究.预测预后预测预测标准死亡率比率标准死亡率比率甲状腺癌是什么?甲状腺癌是什么?

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