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相关概念视频

Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

5.3K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
5.3K
What is the Immune System?01:38

What is the Immune System?

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Overview
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

3.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

8.2K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
8.2K
Development of Immunocompetence01:22

Development of Immunocompetence

453
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
453

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相关实验视频

Updated: Sep 16, 2025

Quantification of the Respiratory Burst Response as an Indicator of Innate Immune Health in Zebrafish
07:07

Quantification of the Respiratory Burst Response as an Indicator of Innate Immune Health in Zebrafish

Published on: September 12, 2013

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训练有素的天生的免疫力

Sayanti Pal1, Zaina Rafiq2, Rekha Kumari3

  • 1Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, UK.

Advances in experimental medicine and biology
|July 7, 2025
PubMed
概括

天生的免疫系统表现出记忆,通过训练有素的免疫系统增强对感染的抵抗力. 利用训练免疫的疫苗提供了广泛的保护,独立于适应性免疫,代表了一种新的免疫战略.

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Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo

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相关实验视频

Last Updated: Sep 16, 2025

Quantification of the Respiratory Burst Response as an Indicator of Innate Immune Health in Zebrafish
07:07

Quantification of the Respiratory Burst Response as an Indicator of Innate Immune Health in Zebrafish

Published on: September 12, 2013

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T Cells Capture Bacteria by Transinfection from Dendritic Cells
11:39

T Cells Capture Bacteria by Transinfection from Dendritic Cells

Published on: January 13, 2016

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Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
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科学领域:

  • 免疫学 免疫学 免疫学
  • 疫苗学 疫苗学 疫苗学

背景情况:

  • 天生的免疫系统具有适应性特征,包括对先前感染的记忆.
  • 像单细胞,巨细胞和NK细胞这样的先天性免疫细胞可以独立于淋巴细胞提供保护.
  • 训练有素的免疫力,持续增强的先天免疫力,增强了对二次感染的抵抗力.

研究的目的:

  • 探索训练免疫在疫苗开发中的潜力.
  • 突出训练免疫基疫苗 (TIbV) 所代表的范式转变.
  • 讨论TIbV如何增强先天性和适应性免疫反应以改善保护.

主要方法:

  • 关于先天性免疫记忆和训练免疫力的研究回顾.
  • 对模式识别受体 (PRR) 参与启动训练免疫的分析.
  • 检查BCG疫苗接种和Mycobacterium manresensis的潜力等例子.

主要成果:

  • 训练免疫是由PRR配体启动的,涉及表观遗传重编程.
  • 接种BCG疫苗会诱导长期的免疫修饰和异质的Th1/Th17反应.
  • 被热杀死的Mycobacterium manresensis在体外显示了诱导训练免疫力的潜力.

结论:

  • 训练有素的基于免疫的疫苗 (TIbV) 为广泛的保护提供了一个新的策略.
  • TIbV可以增强先天性和适应性免疫力,提高常规疫苗的疗效.
  • 将训练有素的天生的免疫力整合到疫苗中,有望增强对传染病的免疫保护.