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关于中国东南地区Yersinia enterocolitica的流行率和基因组洞察 (2008-2022)

Lei Fang¹, Shuxuan Li², Jie Rong³

¹Department of Critical Care Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Applied microbiology and biotechnology

|July 7, 2025

概括

在中国,Yersinia enterocolitica 在食物和动物中很常见. 许多菌株具有多药性耐药性,这凸显了更好的食品安全和抗生素控制的必要性.

科学领域:

通过食物传播的病原体
微生物学微生物学
基因组学就是基因组学.
公共卫生公共卫生

背景情况:

叶菌 (Yersinia enterocolitica) 是一种主要的食源性病原体,导致全球性胃肠道疾病.
中国东南地区缺乏强制性的yersiniosis监测,需要对Y. enterocolitica风险进行评估.
了解Y. enterocolitica的流行和遗传构成对于公共卫生至关重要.

研究的目的:

调查中国东南部Yersinia enterocolitica的流行情况和基因组特征.
为了确定Y. enterocolitica的潜在来源和传播途径.
评估Y. enterocolitica分离物的抗菌素耐药性模式.

主要方法:

从2008年到2022年收集和分析了2939个样本 (动物,零售肉类,其他食品,人类病例).
隔离并确定了105种Y. enterocolitica菌株.
执行了生物类型,序列类型 (ST),植物遗传学分析和抗菌素敏感性测试.

主要成果:

在动物 (8.1%) 和零售肉类 (7.1%) 中,Y. enterocolitica 的流行率高.
准备好吃的沙拉,海鲜和冷食品被确定为潜在的传播媒介.
确定了12种新的STs;生物型1A显示出高遗传多样性. 46.7%的分离物是多药耐药 (MDR),对多素B,亚齐思罗米辛和硫胺异醇具有高耐药性.

结论:

在中国东南部,Y. enterocolitica表现出生态复杂性和多样性,包括非致病菌株.
加强食品安全措施和抗菌药物管理对于减轻公共卫生风险至关重要.
致病菌株与血统HC1490_2有关,在生物型3和4中发现了更高的MDR水平.

关键词:

这种植物是Yersinia enterocolitica.生物型 1 A 生物型通过食物传播的传播.基因组流行病学基因组流行病学动物性传染病是动物性传染病.

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