在儿童中早期发病的新生儿感染和
Mads Andersen1,2, Niels Bjerregård Matthiesen2,3, May Murra4
1Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.
JAMA network open
|July 7, 2025
概括
早发的新生儿败血症会使儿童的风险增加一倍. 早期出现的脑膜炎显著增加了风险,培养验证的脑膜炎显示了最高的关联.
科学领域:
- 神经学 神经学
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
背景情况:
- 是儿童中普遍存在的一种神经系统疾病.
- 早期发病的新生儿感染和儿童的发展之间的联系尚未得到充分理解.
研究的目的:
- 调查早期发病的新生儿感染,特别是败血症和脑膜炎,以及随后患儿的风险之间的联系.
主要方法:
- 一项全国性的基于人口的队列研究包括1997-2013年期间的丹麦活生生的独生子 (妊娠年龄≥35周).
- 早期发病的感染被定义为生命第一个星期内的侵入性细菌感染 (诊断为败血症/脑膜炎或培养阳性).
- 的诊断是基于医院记录或抗药物处方,使用考克斯回归和发病率比率进行分析.
主要成果:
- 这项研究分析了981,869名儿童,其中8,154名被诊断为败血症,152名患有脑膜炎.
- 被诊断为败血症的儿童患的风险增加了1.85倍 (HR,1.85;95% CI,1.60-2.13).
- 早发性脑膜炎的风险明显高,诊断和培养阳性病例与风险分别增加了大约10倍和16倍.
结论:
- 早期发病的新生儿败血症与儿童风险显著增加有关.
- 早期出现的脑膜炎与败血症相比,患的风险要大得多.
- 这些发现强调了预防和管理新生儿感染的重要性,以减轻长期的神经系统后果,如.
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