冠心病患者的炎症负担指数和预后之间的关联:一项回顾性研究
Wen Lu1, Xiaoqin Liao2,3, Yan Jiang1
1School of Nursing, Fujian Medical University, Fuzhou, Fujian, China.
PloS one
|July 7, 2025
概括
炎症负担指数 (IBI) 是一种新的生物标志物,表明冠心病 (CHD) 患者的不良结果风险更高. 较高的IBI水平与增加的重大心血管和脑血管不良事件 (MACCE) 有关.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 系统性炎症 系统性炎症
背景情况:
- 系统性炎症是冠心病 (CHD) 不利预后的一个重要因素.
- 炎症负担指数 (IBI) 是一种反映系统性炎症的新型生物标志物.
- 调查IBI和CHD患者预后之间的关联至关重要.
研究的目的:
- 研究炎症负担指数 (IBI) 与冠心病 (CHD) 患者的预后之间的关联.
- 确定IBI是否可以预测心血管和脑血管不良事件 (MACCEs) 在CHD患者中.
- 探索IBI水平与特定不良结果之间的关系,如新发性心房动 (NOAF) 和对比诱导性病 (CIN).
主要方法:
- 从2017年12月到2022年12月对2453名心血管疾病患者的回顾性分析.
- IBI计算为中性粒细胞/淋巴细胞*C反应蛋白,患者按基线IBI四分位数分组.
- 用于评估IBI对MACCE,NOAF和CIN的预测值的多变量逻辑回归和受限立方线 (RCS) 分析.
主要成果:
- 较高的IBI水平,特别是IBI≥45.68,与MACCEs的风险增加有关.
- 基线IBI在心脏病患者中独立预测了新发性心房动 (NOAF) (OR:2.05) 和对比诱导的脏病 (CIN) (OR:1.95).
- RCS分析证实了IBI和NOAF之间的线性关系,以及与CIN的非线性关系.
结论:
- 炎症负担指数 (IBI) 是心血管疾病患者全身炎症的一个有前途的生物标志物.
- 较高的IBI水平与不良预后和MACCEs风险增加有关.
- 这些发现支持IBI用于精确的临床决策,以改善心脏病患者的治疗结果.
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