缩短母体和胎儿端粒长度与胎儿发育异常之间的关联
Océane Coudrieu1, Zangbéwendé Guy Ouedraogo1,2, Denis Gallot3
1Cytogénétique Médicale, CHU Estaing; Université Clermont Auvergne, UFR de Médecine et professions paramédicales, Clermont-Ferrand, France.
PloS one
|July 7, 2025
概括
胎儿和母亲的端粒长度缩短 (TL) 与先天性异常有关. 孕产妇的TL可以作为胎儿发育异常的预测生物标志物,为早期风险评估提供潜力.
科学领域:
- 生殖生物学 生殖生物学
- 遗传学 是一个遗传学.
- 发展生物学 发展生物学
背景情况:
- 胎儿发育异常受到内在,母体和环境因素的影响.
- 之前的研究表明,胎液端粒长度 (TL) 在发育异常的胎儿中减少.
- 端粒缩短与细胞衰老和基因组不稳定性有关.
研究的目的:
- 调查胎儿和母亲端粒长度 (TL) 与先天性形之间的关联.
- 评估母体TL作为预测胎儿发育异常的潜在生物标志物.
- 探索与先天性异常的怀孕中母亲和胎儿TL之间的相关性.
主要方法:
- 在75个具有先天性缺陷的怀孕中测量胎儿和母亲的TL.
- 病例中的TL与50个没有胎儿异常的怀孕和50个非怀孕的对照进行比较.
- 接收器运行特征 (ROC) 分析,以评估母体TL的预测值.
主要成果:
- 与对照组相比,患有先天性异常的胎儿的胎儿端粒显著缩短 (P < 0.0001).
- 在胎儿异常 (P < 0.01) 的情况下,年龄调整后母亲的TL也显著降低 (P < 0.01).
- 孕产妇的TL在识别先天性异常方面表现出92%的特异性和73%的敏感性,与胎儿的TL有很强的相关性 (15-38%的差异).
结论:
- 胎儿和母亲的端粒缩短与先天性异常有关.
- 孕产妇的TL是胎儿发育异常的潜在预测生物标志物,特别是在经受孕期测量时.
- 端粒缩短可能会通过减少细胞增殖或基因组不稳定性导致受损器官生成.
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