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Updated: Sep 16, 2025

Characterizing Mutational Load and Clonal Composition of Human Blood
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在出生死亡过程中的单细胞突变负担分布.

Christo Morison1, Dudley Stark1, Weini Huang1,2

  • 1School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom.

PLoS computational biology
|July 7, 2025
PubMed
概括

这项研究引入了动态矩阵来统一癌症突变统计数据,如位点频谱 (SFS) 和突变负担分布 (MBD). 新的框架揭示了细胞分裂分布 (DD) 如何影响瘤进化和突变积累.

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