渴望,冲动和随后的甲胺使用与纳尔特雷克松-布鲁对比安慰剂:随机临床试验的发现
Journal of addiction medicine
|July 7, 2025
概括
更高的渴望和冲动性预测了甲基胺的使用. 了解这些因素可以帮助优化用纳尔德和布罗治疗甲基胺使用障碍 (MUD).
科学领域:
- 临床心理学 临床心理学
- 心理药理学 心理药理学
- 成 药物 药物 药物 药物
背景情况:
- 甲基胺使用障碍 (MUD) 是一个重要的公共卫生问题.
- 药物治疗,包括延长释放注射性纳尔特雷克松 (NTX) 和口服布罗 (BUP),对MUD治疗有希望.
- 在MUD中预测治疗反应的预测因素需要进一步调查.
研究的目的:
- 为了确定是否渴望和冲动水平预测后续的甲基胺在接受药物治疗的个人使用.
- 分析增剂药疗治疗加速发展 (ADAPT-2) 试验的二次结果.
主要方法:
- 从ADAPT-2试验中对357名参与者的二次分析.
- 纳入标准:在最初的6周内,尿液药物查 (UDS) 状态至少发生一次过渡.
- 通过视觉模拟尺度 (VAS) 评估渴望;通过简洁健康风险跟踪 (CHRT) 尺度评估冲动性.
主要成果:
- 在NTX-BUP和安慰剂组中,更高的渴望水平与从阳性到阴性UDS过渡的可能性较低有关.
- 冲动性也显著影响了从阳性到阴性UDS过渡的概率.
- 渴望较低,冲动性较高的个体有较低的UDS过渡负面的机会.
结论:
- 渴望和冲动性是MUD治疗结果的重要预测因素.
- 需要进一步的研究来优化NTX-BUP治疗,考虑渴望和冲动性的作用.
- 这些发现可以为MUD提供个性化的治疗策略.
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