氧化应激参数在内脏和皮下脂肪组织中受到西方饮食和间歇性禁食的不同调节
Niedson Correia de Lima Junior1, Thayara Fernandes-Batista2, Letícia Ferreira-Serra2
1Biochemestry, UNICAMP, Campinas, Brazil.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
|July 7, 2025
概括
间歇性禁食并没有防止西方饮食诱导的内脏脂肪氧化应激,尽管减少了炎症. 西方饮食削弱了禁食的作用.
科学领域:
- 代谢和营养 代谢和营养
- 生理学 生理学 生理学
- 生物化学 生物化学
背景情况:
- 西方饮食中高含糖和和脂肪有助于肥胖和氧化应激.
- 间歇性禁食是一种潜在的肥胖干预措施,但它对脂肪组织氧化还原平衡的影响尚未完全理解.
研究的目的:
- 研究间歇性禁食对西方饮食的老鼠内脏和皮下脂肪组织中氧化应激和炎症的影响.
主要方法:
- 雄性Wistar大鼠被食常规或西方饮食*ad libitum*或接受间歇性禁食 (禁食1天,反2天) 持续12周.
- 在内脏和皮下脂肪组织中评估了超氧化离子水平,NADPH氧化酶和催化酶活性,超氧化异变酶活性和Interleukin-6 mRNA水平.
主要成果:
- 西方饮食增加了内脏脂肪组织中的超氧化离子水平,伴随着NADPH氧化酶的减少和catalase活性的增加,表明了适应性反应.
- 在内脏脂肪组织中,超氧化物脱酶活性降低,可能导致超氧化物水平升高.
- 间歇性禁食增加了catalase和superoxide dismutase的表达,但不增加活性,并降低了Interleukin-6mRNA水平,表明具有抗炎作用.
- 皮下脂肪组织的氧化还原平衡没有受到影响.
结论:
- 间歇性禁食本身并不能完全抵消西方饮食引起的内脏脂肪组织中氧化应激.
- 间歇性禁食在内脏脂肪组织中表现出抗炎作用,尽管西方饮食.
- 西方饮食似乎阻碍了间歇性禁食对内脏脂肪组织抗氧化活性的积极影响.
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